AustralieFrV1, Main, Exploration, bibRecord, 001C32

Intrinsic versus Extrinsic Cancer Risks: The Debate Continues.

Identifieur interne : 001C32 ( Main/Exploration ); précédent : 001C31; suivant : 001C33

Intrinsic versus Extrinsic Cancer Risks: The Debate Continues.

Auteurs : Frédéric Thomas [France] ; Benjamin Roche [France] ; Beata Ujvari [Australie]

Source :

Trends in cancer [ 2405-8025 ] ; 2016.

RBID : pubmed:28741552

Abstract

Deciphering the relative contribution of intrinsic (e.g., genetic) and extrinsic (e.g., life style, environmental) risk factors in cancer development is crucial for strategizing cancer prevention. The recent publication by Wu and colleagues in Nature appears as an important contribution to the debate previously initiated by Tomasetti and Vogelstein in Science, who proposed that two-thirds of cancers can be attributed to random mutations and hence 'bad luck'. By contrast, Wu and colleagues, using four lines of evidence, suggest that cancer risk is dominated by extrinsic factors, and intrinsic risk factors only contribute marginally. The debate remains open, and an approach focusing on the evolutionary ecology of organs could provide crucial insights.

DOI: 10.1016/j.trecan.2016.01.004
PubMed: 28741552

Affiliations:

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Serveur d'exploration sur les relations entre la France et l'Australie

Intrinsic versus Extrinsic Cancer Risks: The Debate Continues.

Intrinsic versus Extrinsic Cancer Risks: The Debate Continues.

Source :

Abstract

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